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开云app官网入口:导师简介—闫尧瑶

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发布者:研究生院 发布时间:开云app官网入口-04-25 浏览次数:


1、个人简历:闫尧瑶,女,1996年8月出生,校聘副教授。主要研究方向为:基于靶标的新药发现及药物化学生物学研究。近年来,以第一作者或共同第一作者身份在J. Med. Chem.、Eur. J. Med. Chem.、Bioorg. Chem.等药物化学主流期刊发表论文数篇。

教育背景

 2018.9-2023.6 安徽医科大学 药开云app官网入口 药物化学专业 医学博士

 2014.9-2018.6  安徽中医药大学 药开云app官网入口 制药工程专业 工学学士

2、近五年主持科研项目情况

 安徽中医药大学高层次人才引进项目,30万,在研,主持

3、近三年发表的代表性学术论文(第一或共同第一作者)

[1].Yao Yao Yan, Xing Xing Zhang, Yun Xiao, Ming Ming Liu and Xin Hua Liu. Design and Synthesis of a 2- Amino-pyridine Derivative as a Potent CDK8 Inhibitor for Anti-colorectal Cancer Therapy [J]. Journal of medicinal chemistry,2022,65(19):13316-13239.(中科院分区药物化学一区,TOP,  IF=7.3)

[2]. Yao Yao Yan, Xing Chen, Yun Xiao, Ming Ming Liu and Xin Hua Liu. Discovery and Anti-Inflammatory Activity Evaluation of a Novel CDK8 Inhibitor through Upregulation of IL-10 for the Treatment of Inflammatory Bowel Disease In Vivo[J]. Journal of medicinal chemistry, 2022,65(10):7334-7362.(中科院分区药物化学一区,TOP,  IF=7.3)

[3]. Yaoyao Yan, Qi Lv, Feilong Zhou, Yujie Jian, Liu Xinhua, Xing Chen and Yong Hu. Discovery of an effective anti-inflammatory agent for inhibiting the activation of NF-κB [J]. Journal of Enzyme Inhibition and Medicinal Chemistry. 2023,38:2225135. (中科院二区,IF=5.6)

[4]. Xing Chen, Yaoyao Yan, Juncheng Du, Xiaobao Shen, Xinhua Liu. Non-peptidyl non-covalent cathepsin C inhibitorEEr bearing a unique thiophene-substituted pyridine: Design, structure-activity relationship and anti-inflammatory activity in vivo[J]. European journal of medicinal chemistry,2022,236:114368.(中科院分区药物化学一区,TOP, IF = 6.5)

[5]. Famin Zhang, Yaoyao Yan , Xu Han, Jun Cheng Du, Rende Zhu, Xin Hua Liu. Design and synthesis of the 4H-chromenone derivatives against psoriasis[J]. Bioorganic chemistry, 2022,120:105640. (中科院分区有机化学一区,TOP, IF = 5.3)

[6]. Xing Chen,Yaoyao Yan, Zhaoyan Zhang, Faming Zhang, Mingming Liu, Jing Bo Shi and Xinhua Liu. Discovery and In Vivo Anti-inflammatory Activity Evaluation of a Novel Non-peptidyl Non-covalent Cathepsin C Inhibitor[J]. Journal of medicinal chemistry, 2021,64(16):11857-11885.(中科院分区药物化学一区,TOP,  IF=7.3)

4、联系方式

Email:yanyaoyao@ahtcm.edu.cn; m19956576997@163.com


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